Two sample MR report
FLOT1_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.0592939 | 0.0579015 | 0.3453149 |
| Weighted median | 8 | 0.0204313 | 0.0107578 | 0.0575375 |
| Inverse variance weighted | 8 | 0.0224649 | 0.0080257 | 0.0051243 |
| Simple mode | 8 | 0.0203892 | 0.0170448 | 0.2705546 |
| Weighted mode | 8 | 0.0193702 | 0.0162451 | 0.2719639 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.310005 | 6 | 0.7690517 |
| Inverse variance weighted | 3.722505 | 7 | 0.8111269 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0241464 | 0.0375959 | 0.5444467 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001714 | 0 | TRUE | 0.2141371 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
